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Projects
Area Vector Fate
Cell entry targeted gene transfer into quiescent cells of the hematopietic system by surface engineered lentiviral vectors
Buchholz, Langen - Cichutek, Langen
Cell entry and intracellular fate of rAAV targeting vectors and their genomes in the lymphohematopoietic system
Büning, Cologne - Hallek, Cologne
Therapeutic gene targeting in human CD34+ cells
Cathomen, Hannover
Generation of improved viral hybrid-vectors for stable transduction of mammalian cells
Ehrhardt, Munich
Directed nuclear targeting of conditionally regulated vector plasmids
Hammerschmidt, Munich - Schepers, Munich
Assessing and improving the safety profile of Sleeping Beauty transposon-mediated gene transfer in human cells
Ivics, Berlin - Izsvak, Berlin
Cytokine-mediated targeting of adenovirus gene transfer vectors for efficient gene delivery to hematopoietic cells
Kreppel, Ulm - Kochanek, Ulm
Control of epigenetic transgene silencing
Leonhardt, Munich
Characterization and Manipulation of Foamy Virus Vector Entry
Lindemann, Dresden
Improvement and application of a non-viral episome for mammalian cells
Lipps, Witten
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Projects
Area Cell Fate
Target cells of insertional transformation in the hematopoietic system
Baum, Hannover - Li, Hannover - Kustikova, Hannover
Epigenetic of Vector-Chromatin Interactions
Grez, Frankfurt
Avoiding MDS/AML in genetic therapy for FA-G with complex retroviral vectors
Hanenberg, Düsseldorf
Control Mechanisms in mature T-Cell Leukemia/Lymphoma
von Laer, Innsbruck / Frankfurt am Main
Humanized models to assess the genotoxicity of viral vectors in the context of hematopoietic stem cell expansion and in vivo selection
Moritz, Hannover - Modlich, Hannover
Mathematical modelling of individual clone dynamics for genetically modified haematopoietic stem cells and mature T-cells
Roeder, Dresden - Loeffler, Leipzig
Development of sensitive and unbiased integration site analyses to comprehensively assess biosafety and efficiency of innovative vectors
Schmidt, Heidelberg - Glimm, Heidelberg - von Kalle, Heidelberg
Therapeutic potential and risk analysis of T cell receptor gene-modified bone marrow stem cells for adoptive T cell therapy
Uckert, Berlin
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